TB & Lipid metabolism

Summary In addition to stress-response systems on the pathogenic side, I studied some host responses to M. tuberculosis infection using computational approaches as well: characterizing the transcriptional response in infected macrophages under various small molecule perturbations using RNA-Seq analysis; understanding the dysregulation of lipid metabolism in M. tuberculosis-infected macrophages using dynamic Bayesian model and statistical analyses of heterogeneous single-cell populations. Related publications Lipid Metabolism and TB, in preparation.

Stochastic nature of adipogenic and inflammatory responses in tuberculous macrophages