Summary
In addition to stress-response systems on the pathogenic side, I studied some host responses to M. tuberculosis infection using computational approaches as well:
- characterizing the transcriptional response in infected macrophages under various small molecule perturbations using RNA-Seq analysis;
- understanding the dysregulation of lipid metabolism in M. tuberculosis-infected macrophages using dynamic Bayesian model and statistical analyses of heterogeneous single-cell populations.
Related publications
- Lipid Metabolism and TB, in preparation.
- Cutting edge: Vitamin D regulates lipid metabolism in Mycobacterium tuberculosis infection
Collaborators
Rutgers University
- Marila Gennaro
- Sanjay Tyagi
- Gili Kaufmann (now in …)
- Richard Pine
- Eduardo Sontag (now in NorthEastern)
- Evgeni ‘Zhenya’ Nikolaev
- Valentina Guerrini
- Natalie Bruiners
Tulane University
- Deepak Kaushal
- Smriti Mehta
Knowledge Synthesis
- Hugh Salamon
- Ken Yamaguchi
