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Bacterial Stress Response

Summary During my postdoctoral research at Rutgers University, I focused on using computational approaches to study various facets of host and pathogen biology including: delineating the molecular mechanism underlying a newly identified stress response operon in the tubercle bacterium involving the phage-shock-proteins (psp); unraveling the evolution of bacterial stress response systems (psp) across the tree of life using protein sequence-structure-function relationships; reconstructing and analyzing the mycobacterial sigma factor regulatory network.

Using computational appraches to understand host-pathogen biology

Variations on a theme: evolution of the phage-shock-protein system in Actinobacteria

Evolution and Conservation of the Psp Envelope Stress-Response System

Microbial Mechanosensing: Phage Shock Protein Response System in Gram-positive Bacteria

The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions

The bacterial envelope integrates essential stress-sensing and adaptive functions; thus, envelope-preserving functions are important for survival. In Gram-negative bacteria, envelope integrity during stress is maintained by the multi-gene Psp …