Summary
During my postdoctoral research at Rutgers University, I focused on using computational approaches to study various facets of host and pathogen biology including:
- delineating the molecular mechanism underlying a newly identified stress response operon in the tubercle bacterium involving the phage-shock-proteins (psp);
- unraveling the evolution of bacterial stress response systems (psp) across the tree of life using protein sequence-structure-function relationships;
- reconstructing and analyzing the mycobacterial sigma factor regulatory network.
Related publications
- The evolution, conservation, and covariation of the Psp envelope-stress-response system across the tree of life, in preparation.
- Variations on a theme: evolution of the phage-shock-protein system in Actinobacteria
- The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions
- Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis
Collaborators
Rutgers University
- Marila Gennaro
- Pratik Datta
- Matt Neiditch
- Arnold Barton
- Rasel Khan
- Rinki Chauhan
NCBI, NIH
- L Aravind
- Vivek Anantharaman
SUNY Buffalo
- Gabor Balazsi
Rice University
- Oleg Igoshin
